PhD project - STARLight – START-domain containing proteins and lutein in eye health

STARLight – START-domain containing proteins and lutein in eye health Project Abstract: Lutein and zeaxanthin are together known as macular pigment (MP) and are considered critical for eye health. Thesecarotenoids are derived from the diet and are commonly used in dietary supplements; they accumulate in the macula ofthe eye through a complex biochemical pathway. START-domain proteins (e.g. STARD3, ASTER-B) have emerged asauthentic lutein-binding proteins within this pathway. Genetic variants leading to alterations in these proteins are commonin the Irish population, but their functional impacts on macular pigment optical density (MPOD) and eye health is not fullyunderstood. This project aims to address this knowledge gap and understand how gene variants impact MPOD. This willbe achieved by measuring MPOD and retinal health in individuals who have had genetic make-up characterised, and thenlinking the genetic and clinical information. The primary aim of the project is to enable personalisation of luteinsupplementation regime according to a person’s gene- variant, using rapid gene assay technology, thereby maximising thehealth effects of the supplements. In addition to this translational aim with short-term impact on optometric practice, thisproject will also advance our understanding of the biochemical pathways governing lutein accumulation. Research Question: What is the impact of functional gene-variants in the START- domain proteins STARD3 and ASTER- B on for accumulationof lutein in the eye, macular pigment optical density (MPOD) and eye function? How do these variants influence the dietaryrequirement for lutein?

Student Requirements: A Bachelor’s or Master’s degree in Optometry, Genetics, Biochemistry, Molecular Biology, or a related field (2.1 or 1.1). Strong academic record and research potential. Excellent communication and teamwork skills. Prior clinical experience is an advantage – CORU Registration is desirable.

Fully Funded (scholarship, fees, materials) Funding agency This project is supported by TU Dublin and funded via the Technological University R&I supporting Enterprise scheme, which is co-financed by the Government of Ireland and the European Union through the ERDF Regional Programme 2021-2027 Student Stipend per annum €25,000 Materials & Travel Budget €2000 for materials with an additional €1500 provided in year 1 to cover the costs of a laptop. €1000 for travel to conferences etc Fees €5500 covered Duration of funding 48 months

If you are interested in submitting an application for this project, please complete an Expression of Interest.

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