The UPDDI is searching for a Postdoctoral Fellow to apply our vascularized human liver microphysiology system (vLAMPS) of non-alcoholic fatty liver disease (NAFLD) using both primary human cells and iPSC-derived cells for application in a project focused on studying mechanisms of NAFLD disease progression, the identification of disease-relevant biomarkers, and the testing of novel NAFLD drug candidates [Saydmohammed M., et al. Exp Biol Med (2021); PMID: 33957803 and Gough A., et al. Nat Rev Gastroenterol Hepatol. (2021); PMID: 33335282]. Great talent in cell-based experimentation, knowledge of liver physiology and the use of imaging systems is required. Biomedical engineers with experience in the design and application of liver MPS systems are also strongly encouraged to apply. This is an excellent opportunity to participate in a highly collaborative team of bio- engineers, cell and molecular biologists, computational biologists, pharmacologists, and clinician-scientists to apply our MPS models of disease to drug discovery. The goal is to identify mechanisms and biomarkers of NAFLD disease progression that can be used to develop new or repurposable drugs for NAFLD implementing a platform focused on human biomimetic liver microphysiology systems (MPS) that uses functional genomic, biochemical, and phenotypic metrics, the microphysiology systems database and quantitative systems pharmacology (QSP).
• Optimize and validate the application of the human, 4 cell-type vLAMPS model of NAFLD with various drug treatments and interpret the biochemical, biosensor, molecular and pathology read-outs.
• Collaborate with the liver microphysiology systems team and clinician-scientists at Pitt.
• Design, plan and execute experiments; analyze and present results in seminars and publications.
• Ph.D in physiology, cell biology, biophysics, biomedical engineering, or related field
• Strong cell-based research experience; previous experience with liver MPS model systems is highly valued.
• Experience in liver cell and organ physiology, cell and molecular biology a plus
• Experience with primary human cells and iPSCs a plus.
The University of Pittsburgh is an Affirmative Action/ Equal Opportunity Employer and values equality of opportunity, human dignity and diversity, EOE, including disability/vets.