GENERAL SUMMARY OF POSITION:
The Research Associate II is responsible to perform upstream cell
culture process development activities supporting generation of stable cell
lines, optimization and scale-up of cell culture processes for the production
of monoclonal antibodies and technical transfer to manufacturing. Additionally,
the Associate II will provide lab coverage during evenings, weekends, and
holidays on a rotating basis, as required to support upstream development
activities. The incumbent will perform established assays and contribute to the
development of new assays.
stable cell lines using molecular cloning techniques.
cell culture maintenance in monolayer, shake flask, spinner flask and
small-scale bench top bioreactor systems for the production of monoclonal
experiments and maintains cell culture logs as required.
analytical biochemistry and molecular biology assays as well as microscopy and
other laboratory testing as required.
accurate records in notebooks, organizes and reports results.
and maintains standard laboratory equipment and departmental specific
equipment. Troubleshoots equipment within scope of experience.
data in Excel and DOE software, and provides accurate, concise data summaries
timely and accurate documentation in accordance with cGMP and MassBiologics’
SOPs. Contributes to the development of improved documentation processes.
to write protocols, project summaries and technical reports.
written and oral reports for presentation to the supervisor(s) and development
reagent and equipment inventories, orders supplies and cleans laboratory areas,
hoods and common equipment.
technical discretion in the design, execution and interpretation of experiments
that contribute to project strategies within defined parameters.
supervise and train lower level personnel.
a bachelor’s degree in Molecular Bology, Cell Biology, or related field with a
minimum 2 years of relevant experience.
on experience with antibody production in mammalian cell culture systems
to follow instructions precisely, recognize deviations, and recommend
corrective action within scope of training.
strong attention to detail, ability to maintain accurate records and excellent
to troubleshoot within scope of training.
critical thinking, time management and organizational skills. Demonstrated
ability to manage and prioritize multiple projects and consistently meet
written and verbal communication skills. Ability to communicate effectively
to work effectively both independently and as a member of a team.
literate and proficient in MS Word, Excel and other relevant electronic
projects require flexibility in work schedule to meet business needs.
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